What is cancer?
A eukaryotic cell has evolved to have robustness. The genome maintains cellular properties against environmental challenges by operating the proteome. Cancer is a state in which the genome has lost the ability to operate the proteome, and the proteome seizes the initiative.
Genomic Modules
Cells perform the tasks assigned by the living body. It is generally rare that the tasks are directly related to the functions of individual genes. Instead, a task is executed by multiple genes that construct a system in most cases. These tasks are related to exhibiting life phenomena of higher order. We, therefore, define the group of genes that make up such a system as a genomic module, the functional unit of the genome.
Keratinization Module in Lung Squamous Cell Carcinoma
Module Activated in Normal Breast Ductal Epithelial Cells
Cell Cycle Regulation and DNA Repair Module
Modular Sample Probability
Given the density matrix of a genomic module separated from a group of reference tissue samples, the degree to which a tissue sample deviates from the reference is calculated as a probability.
Why mRNA Data?
To understand the large-scale control from the genome over the proteome for the expression of cell characteristics and to find out the abnormalities in this control system in cancer, it is necessary to analyze the amount of mRNA of the whole genome measured simultaneously.
